The following programs are gzip'ed tar archives, and are designed to run under a UNIX/Linux operating system. Please email to get a copy of these programs.
SUP: an extension to SLINK to allow a larger number of marker loci to be simulated in pedigrees conditional on trait values and in linkage equilibrium or disequilibrium with a trait locus. SUP now supports the X chromosome.
GENEHUNTER++sad: implementation of the Sad statistic, more robust to transmission ratio distortion in the context of allele sharing.
SimM: a gene dropping simulation software.
nucular: a program that splits extended pedigrees into nuclear families, with the option of recoding all sibs as half-sibs with distinct mothers of fathers.
The description of SimM can be found here:
The description of nucular can be found here:
The articles related to the above programs can be found following these links:
Lemire M (2006) SUP: An extension to SLINK to allow a larger number of marker loci to be simulated bin pedigrees conditional on trait values. BMC Genetics 2006, 7:40 (about SUP)
Lemire M, Roslin NM, Laprise C, Hudson TJ, Morgan K (2004) Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3. Am J Hum Genet 75:571–586 (about GENEHUNTER++sad and SimM)
Lemire M (2005) A simple nonparametric multipoint procedure to test for linkage through mothers or fathers as well as imprinting effects in the presence of linkage. BMC Genetics 2005, 6(Suppl 1):S159 (about nucular)
[Mathieu Lemire's Contact Information]